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KMID : 0900919920160020149
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Korean journal of Animal Reproduction
1992 Volume.16 No. 2 p.149 ~ p.155
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Studies on the Changes of Steroid Hormone Levels during the Reproductive Stage in Korean Native Goats III. Seroum Levels of Progesterone and 20alpha-Dihydroprogesterone before and after Parturition
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Min Kwan-Sik
Oh Seok-Doo
Seong Hwan-Hoo
Yun Chang-Hyeon
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Abstract
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The present study was conducted to find out the changes of progesterone and 20alpha-dihydroprogesterone(20alpha-OHP) levels before and after parturition, 4 pluriparous goats were offered for this experiment. Blood samples were taken from jugular vein on Days, 5, 3, 2 and 1 before parturition, the day of parturition, 1, 3, 5, 7 and 9 after parturition. The blood samples were centraifuged and stored at -20^{circ}C until hormone assay. The serum levels of progesterone and 20alpha-OHP were measrued by radioimmunoassay. The changes of serum progesterone level during peripartum period were characterized as a remarkable decrease. The progesterone level was 4.05pm0.52ng/ml on 56 days before parturition and decreased to 2.24pm0.38ng/ml on 1 day before parturition and 0.79pm0.09ng/ml on the day of parturition and the basal level was maintained through 9 days of postpartum period. The serum level of 20alpha-OHP during the peripartum period was 1.25pm0.21ng/ml on 5 days before paturition and increased to 1.32pm0.25 on 3 days and 1.59pm0.24ng/ml on 1 day before parturition, and reached a peak level of 1.78pm0.25ng/ml just prior to parturition and then decreased greatly to 0.31pm0.03ng/ml on 1 day postpartum and the basal level was remained until 9 days postpartum. The high serum level of 20alpha-OHP, which was peak just prior to parturition, was maintained for 2 days following the onset of remarkable decrease in the serum level of progesterone. From the above results, it was concluded that the enzyme 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) catalyzing the conversion of progesterone to a biologically inactive steroid, 20alpha-OHP was active properly in the luteal cells in Korean native goats.
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KEYWORD
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progesterone, 20alpha-dihydroprogesterone, before and after parturition
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